Polygonum bistorta contains phytochemical compounds that can affect coagulation. It is used as hemorrhoid for bleeding control in traditional medicine. For its in vivo evaluation, 35 mice were randomly divided into 5 groups (n = 7) as well as the negative and positive control. On the 13th day of treatment, blood samples were collected for bleeding time (BT), clotting time (CT) and the number of platelets and on the 14th day, for prothrombin time (PT), activated partial thromboplastin time (aPTT). The results were shown although P. bistorta extract had a significant reducing effect on all coagulation tests in a dose-dependent manner, the greatest reduction in coagulation time (16. 5 times) in the CT test and the best significant dosage is 1000 mg/kg/day shows that the P. bistorta extract has a greater effect on the common pathway than intrinsic and extrinsic pathways.

Background: Exposure to hand– arm vibrations higher than permissible standard rates can have destructing effects on workers’ health. Pneumatic hammers are among the tools that are used in civil and industrial projects, transferring high vibration acceleration to the workers. This study has considered the probable effects of hand– arm vibrations on the performance of blood coagulation factors in the workers using this tool and exposed to high vibration acceleration. Methods: Five new workers without any experience in exposure with hand– arm vibrations were selected for this interventional study. Blood sample was taken from each worker before they started working for the required analysis. Sampling was repeated in two other stages in 2‑ month intervals from the first sampling, whereas the workers were then experienced in working with pneumatic hammers. Measuring the vibration of the pneumatic hammer was done according to ISO 28927‑ 10 standard. Results: The point of measuring the vibration acceleration was selected close to the hand, in accordance with the standard. Regarding the exposure time of the workers, the amount of vibration acceleration was obtained 15. 54 m/s2. Activated partial thromboplastin times of four samples in the second and third stages have shown increases in comparison to the first stage in that respect. On the other hand, a number of red blood cells, white blood cells, and platelets did not show a consistent trend in the three stages. Conclusions: The considered samples showed longer time for blood coagulation as compared to the reference time. Thus, it can be concluded that the main reason is the acceleration in three different coordinate axes of x, y, and z. Hence, the values beyond permissible standard rate of hand– arm vibration in 8 h shifts affect the blood parameters, among which the considered coagulation parameters in this study showed more tangible changes in that respect.

Introduction: Evidence suggests a link between serum adropin levels and coagulation factors, with physical activity boosting adropin circulation. This study investigates the correlation between adropin and blood coagulation factors in young adults at varying activity levels. Material & Methods: Fifty healthy young adults were divided into active and inactive groups using the Baecke questionnaire. Blood samples assessed adropin and coagulation factors. Statistical tests included Mann-Whitney and independent t-tests for comparison, with Spearman's correlation coefficient determining strength. Results: Active participants exhibited significantly lower fibrinogen (p<0.05) and higher adropin levels (p<0.05) compared to inactive peers. Physical activity correlated negatively (r=-0.27, p=0.05) with fibrinogen but not with adropin and other coagulation factors. Conclusion:  Elevated physical activity levels correlate with heightened serum adropin and reduced serum fibrinogen. Moreover, serum fibrinogen, a critical coagulation factor influencing blood clot formation, appears particularly sensitive to the effects of physical activity.

Background: Preeclampsia is an idiopathic multisystem disorder specific to human pregnancy and the puerperium and hematological abnormalities may develop in preeclamptic women. This study was designed to determine coagulation parameters in patients with severe preeclampsia in Shiraz, southern Iran.Methods: From 2002 to 2005, coagulation indices including platelet count, prothrombin time (PT), activated partial thromboplastin time (aPPT), plasma fibrinogen, and fibrin degradation products (FDP) were measured within 24 hours of admission for fifty women with severe preeclampsia and fifty normal pregnant women. The patients with coagulopathies were excluded. Abnormal coagulation indices were compared between the two groups.Results: The mean value of platelet counts were significantly lower while the mean values of aPPT and FDP were higher in the preeclamptic patients. However, the mean values of plasma fibrinogen and PT did not show any statistical difference between these two groups. Fifty percent of the patients with severe preeclampsia showed thrombocytopenia, 10% prolonged PT, 30% prolonged PTT, 28% hypofibrinogenemia, and 32% elevated FDP. Prolonged aPTT was seen in 6% of patients with platelet counts of more than 150´103/mm3 at the admission time. However, these patients showed evidence of coagulopathies and needed to receive blood or blood products later in their hospital course.Conclusion: In case an abnormal platelet count or aPTT is detected in a patient with severe preeclampsia, a coagulopathic disorder should be clinically suspected.